diff --git a/CHANGELOG.md b/CHANGELOG.md
index 9c8426c8e00d..17df37f2fb51 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,7 @@ The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/).
 - Added support for graph-level outputs in `to_hetero` ([#4582](https://github.com/pyg-team/pytorch_geometric/pull/4582))
 - Added `CHANGELOG.md` ([#4581](https://github.com/pyg-team/pytorch_geometric/pull/4581))
 ### Changed
+- Allow for `setter` properties in `Data` and `HeteroData` ([#4682](https://github.com/pyg-team/pytorch_geometric/pull/4682))
 - Allow for optional `edge_weight` in `GCN2Conv` ([#4670](https://github.com/pyg-team/pytorch_geometric/pull/4670))
 - Fixed the interplay between `TUDataset` and `pre_transform` that modify node features ([#4669](https://github.com/pyg-team/pytorch_geometric/pull/4669))
 - Make use of the `pyg_sphinx_theme` documentation template ([#4664](https://github.com/pyg-team/pyg-lib/pull/4664), [#4667](https://github.com/pyg-team/pyg-lib/pull/4667))
diff --git a/test/data/test_data.py b/test/data/test_data.py
index 3733072cc508..b794364be308 100644
--- a/test/data/test_data.py
+++ b/test/data/test_data.py
@@ -213,3 +213,29 @@ def test_data_share_memory():
     for data in data_list:
         assert data.x.is_shared()
         assert torch.allclose(data.x, torch.full((8, ), 4.))
+
+
+def test_data_setter_properties():
+    class MyData(Data):
+        def __init__(self):
+            super().__init__()
+            self.my_attr1 = 1
+            self.my_attr2 = 2
+
+        @property
+        def my_attr1(self):
+            return self._my_attr1
+
+        @my_attr1.setter
+        def my_attr1(self, value):
+            self._my_attr1 = value
+
+    data = MyData()
+    assert data.my_attr2 == 2
+
+    assert 'my_attr1' not in data._store
+    assert data.my_attr1 == 1
+
+    data.my_attr1 = 2
+    assert 'my_attr1' not in data._store
+    assert data.my_attr1 == 2
diff --git a/torch_geometric/data/data.py b/torch_geometric/data/data.py
index 0a778214a582..a6bc90710d89 100644
--- a/torch_geometric/data/data.py
+++ b/torch_geometric/data/data.py
@@ -375,7 +375,11 @@ def __getattr__(self, key: str) -> Any:
         return getattr(self._store, key)
 
     def __setattr__(self, key: str, value: Any):
-        setattr(self._store, key, value)
+        propobj = getattr(self.__class__, key, None)
+        if propobj is None or propobj.fset is None:
+            setattr(self._store, key, value)
+        else:
+            propobj.fset(self, value)
 
     def __delattr__(self, key: str):
         delattr(self._store, key)