diff --git a/Lib/test/test_urllib2.py b/Lib/test/test_urllib2.py
index a2b1340e0bf5ba..fb2541bff89cf8 100644
--- a/Lib/test/test_urllib2.py
+++ b/Lib/test/test_urllib2.py
@@ -1791,9 +1791,10 @@ class MyOtherHTTPHandler(urllib.request.HTTPHandler):
     @unittest.skipUnless(support.is_resource_enabled('network'),
                          'test requires network access')
     def test_issue16464(self):
-        with socket_helper.transient_internet("http://www.example.com/"):
+        url = "http://httpbin.org/post"
+        with socket_helper.transient_internet(url):
             opener = urllib.request.build_opener()
-            request = urllib.request.Request("http://www.example.com/")
+            request = urllib.request.Request(url)
             self.assertEqual(None, request.data)
 
             opener.open(request, "1".encode("us-ascii"))
diff --git a/Misc/NEWS.d/next/Tests/2022-02-05-18-58-37.bpo-46648.EJUGbT.rst b/Misc/NEWS.d/next/Tests/2022-02-05-18-58-37.bpo-46648.EJUGbT.rst
new file mode 100644
index 00000000000000..970b798a576a98
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2022-02-05-18-58-37.bpo-46648.EJUGbT.rst
@@ -0,0 +1,3 @@
+The test_issue16464() test of test_urllib2 now uses
+``http://httpbin.org/post`` URL instead of ``http://www.example.com/``.
+Patch by Victor Stinner.